J4145
Sigma
Jervine
≥98% (HPLC), solid
| Synonym: | (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine |
| CAS Number: | 469-59-0 |
| Linear Formula: | C27H39NO3 |
| Molecular Weight: | 425.60 |
| EC Number: | 207-417-9 |
| MDL number: | MFCD01684066 |
| PubChem Substance ID: | 24896194 |
Description
| Biochem/physiol Actions | Jervine is a sonic hedgehog (Shh) pathway inhibitor. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | methanol: >2 mg/mL |
| H2O: insoluble | |
| Gene Information | human ... EBP(10682) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | WG9700000 |
References
| reference | Williams, J.A., et al., Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basla cell carcinoma-like lesions. Proc. Natl. Acad. Sci. U. S. A. 100, 4616-4621, (2003) |
| Mistretta, C.M., et al., Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locationa in dorsal lingual epithelium. Dev. Biol. 254, 1-18, (2003) |
